The discussion centers on the perception of reality in individuals with schizophrenia and dissociative identity disorder (DID), exploring how certain brain functions may contribute to feelings of unreality. Participants express skepticism about attributing these experiences solely to specific brain regions, emphasizing the complexity of brain chemistry and psychology. The conversation references an NIH article and a Mayo Clinic resource that describe conditions like depersonalization and derealization, which affect how individuals perceive reality. There is debate over the validity of fMRI studies and blood tests in establishing connections between brain activity and perceptions of reality, with some participants questioning the reliability of such scientific methods. The discussion also touches on the relationship between a person's sense of connection to the world and their overall functionality, suggesting that cognitive differences, such as those seen in genius or autistic individuals, may influence their perception of reality. The thread was temporarily closed for moderation.