The discussion explores the concept of graphing a piece of music and finding its derivative, focusing on how this mathematical operation could affect the sound. It suggests that the derivative of a musical function, defined by pitch over time, would represent the instantaneous rate of change of pitch, resulting in higher pitches for fast notes and lower pitches for slower ones. The conversation also touches on the Fourier Transform, indicating that the second derivative would alter the frequency and phase of the sound, potentially making it unrecognizable. Participants emphasize the relationship between high frequency and rapid changes in pitch, noting that the method of sampling is crucial for accurately calculating derivatives from time series data. Overall, the exploration highlights a fascinating intersection of music and calculus, suggesting that mathematical transformations can significantly alter musical perception.