Effect of Mutation on Peptide Sequence: Wild Type vs. Mutant

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Discussion Overview

The discussion revolves around the effects of a mutation on a peptide sequence, comparing the wild type and mutant sequences. Participants are examining the implications of a specific nucleotide change on the resulting amino acid sequence and its properties.

Discussion Character

  • Homework-related

Main Points Raised

  • One participant presents a wild type peptide sequence and a mutated version, asking for the effects of the mutation.
  • Another participant requests the original poster to share their answer to adhere to forum rules.
  • The original poster indicates they chose option B, which suggests one amino acid is replaced by another with different properties, but notes that the answer key states option D, indicating the peptide is one amino acid shorter.
  • A later reply from the original poster suggests they have identified a mistake in their reasoning regarding the mutation's effect.

Areas of Agreement / Disagreement

The discussion reflects disagreement regarding the correct interpretation of the mutation's effect, with one participant asserting their choice and another providing a conflicting answer from the answer key. The original poster's later realization indicates uncertainty about their initial conclusion.

Contextual Notes

Participants have not fully resolved the implications of the mutation, and there may be missing assumptions regarding the interpretation of the codon table and the specific nature of the mutation.

iacephysics
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this is a very easy question from my exam last night, i think the answer key is wrong. so tell me what you think the right answer is.

the wild type sequence of the template strand for a peptide is

5' - TCACCCGTAGAGCAT -3'

Identiful the effect of the mutation:

5' - TCACCCCTAGAGCAT - 3'

A. one amino acid replaced by another with similar properties.
B. one amino acid replaced by another with different properties.
C. same primary sequence.
D. the resulting peptide will be once amino acid shorter than the wild type.

here's the codon table that you may need:
http://www.cs.cmu.edu/~blmt/Seminar/SeminarMaterials/codon_table.jpg
 
Last edited:
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You need to tell us which is your answer first. PF rules.
 
i chose B on the exam. but the answer key says D.
 
oh crap, nevermind, i figured out wher my mistake is.
 

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