nobahar
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I'm sure someone has mentioned it, but this always happens:
Imbecile, moron, and so on. It starts off as a medical term and is then used in a derogatory manner.
The worst offender has to be when people say "Schizo", or someone's behaviour, opinion, etc, is "Schizophrenic"; considering that its always used incorrectly. They use Schizophrenic when they mean Dissociative Identity Disorder. Even people who you expect to know better do it (e.g. I was disappointed to see Christopher Hitchens use it incorrectly).