One has to be careful. If it comes to scattering processes one should rather think in terms of quantum field theory rather than classical point-particle mechanics (which is anyway a problematic topic in relativity when it comes to interactions). Here it comes clear that a particle interpretation of the quantum fields, which are the fundamental mathematical entities in the description of particles in realtivistic QFT, is only possible for asymptotic free states (and even this is a more complicated notion than often thought). In a naive sense you can define them as Fock states of the various quantum fields describing particles in a situation, where the particles are located so far distant from each other that all interactions are negligible. A one-particle basis of these states is then defined by the momentum-spin eigenstates, which are automatically also energy eigenstates, where the relation between energy and momentum is
$$E^2=m^2 c^2 + \vec{p}^2.$$
That's the so-called mass shell in momentum space.
Scattering processes are then described by the socalled S-matrix. The S-matrix elements (or rather their modulus squared) describe a transition rate for a process described by a reaction, where (usually) two asymptotic free particles are shot at each other, then interact and then the reaction products fly appart and what's measured are then the asymptotic free particle states (usually many particles, which can be different from the original particles) corresponding to the reaction you are interested in. That's usually done with help of perturbation theory using Feynman diagrams, which are mainly just a very clever notation of the corresponding mathematical formulae but also provide, if correctly interpreted, a quite intuitive picture of the scattering process. For these scattering processes the energies and momenta (or in relativistic lingo their four-momenta) of the incoming and outgoing asymptotic free particles always (a) obey their corresponding on-shell conditions and (b) overall energy and momentum conservation, i.e.,
$$p_1+p_2=p_1'+p_2'+p_3'+\cdots,$$
where ##p_1## and ##p_2## are the on-shell four-momenta of the incoming asymptotic free particles and the ##p_1'##, ##p_2',\ldots## those of the outgoing asymptotic free particles.
It should be understood that a particle interpretation of the quantum state of the involved quantum fields during the scattering process itself, where the states are not asymptotically free, no particle interpretation is possible. Often one refers to the corresponding internal lines of Feynman diagrams of perturbation theory as "virtual particles", but that's just the usual physicists' slang which has to be understood in the right way. What's physically observable are the asymptotic free states and, through making measurements of very many scattering processes, the probabilities (encoded in terms of cross sections) for certain scattering processes calculated from the S-matrix elements.