Flawed interferon response spurs severe COVID-19

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Tom.G
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from: Science magazine:

"...in a significant minority of patients with serious COVID-19, the interferon response has been crippled by genetic flaws or by rogue antibodies that attack interferon itself.

And appears to be related to a flawed X chromosome that creates antibodies to type I interferons, which helps explain why males are more likely to be severely ill.

https://science.sciencemag.org/content/369/6511/1550
https://science.sciencemag.org/content/369/6511/1550/tab-pdf

Cheers,
Tom
 
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