- A team of researchers from a Duke University found that several different general anesthesia drugs knock out the patient by hijacking the neural circuitry that the person falls asleep.
Rather than inhibiting neurons, anesthesia could also activate individual neurons in the brain A medical miracle happened about 170 years ago when scientists discovered general anesthesia that enables millions of patients to undergo invasive, life-saving surgeries without pain.
In a new study published online in Neuron, scientists believe they have discovered the part of the answer. A team of researchers from a Duke University found that several different general anesthesia drugs knock out the patient by hijacking the neural circuitry that the person falls asleep.
Does this disprove the soliton model of neuroscience?
https://en.wikipedia.org/wiki/Soliton_model_in_neuroscience specifically "Application to anesthesia"
"The authors claim that their model explains the previously obscure mode of action of numerous anesthetics. The Meyer–Overton observation holds that the strength of a wide variety of chemically diverse anesthetics is proportional to their lipid solubility, suggesting that they do not act by binding to specific proteins such as ion channels but instead by dissolving in and changing the properties of the lipid membrane. Dissolving substances in the membrane lowers the membrane's freezing point, and the resulting larger difference between body temperature and freezing point inhibits the propagation of solitons. By increasing pressure, lowering pH or lowering temperature, this difference can be restored back to normal, which should cancel the action of anesthetics: this is indeed observed. The amount of pressure needed to cancel the action of an anesthetic of a given lipid solubility can be computed from the soliton model and agrees reasonably well with experimental observations."