To simplify or solve the equation A^2 + B^2 * C^2 = C^2, it is noted that A, B, and C are integers. If |B| > 1, then B^2 * C^2 exceeds C^2, leading to the conclusion that A^2 must be non-negative. This implies that the values of B are limited, as they must satisfy the condition of the equation. The discussion encourages exploring these constraints further to find potential solutions. Ultimately, the focus is on determining the valid integer values for B that allow the equation to hold true.