How does a Gas Chromatograph-Mass Spectrometer detect quantities?

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SUMMARY

The discussion centers on the detection and quantification of molecules using Gas Chromatography-Mass Spectrometry (GC-MS). Participants highlight the role of the mass analyzer in identifying fragments based on their mass-to-charge ratio and emphasize the importance of the Total Ion Chromatogram (TIC) in quantifying the amount of each fragment. The conversation seeks clarity on how the GC-MS system measures the quantity of detected fragments, indicating a need for further resources on the detection methods employed by these instruments.

PREREQUISITES
  • Understanding of Gas Chromatography (GC) principles
  • Familiarity with Mass Spectrometry (MS) techniques
  • Knowledge of mass-to-charge ratio (m/z) concepts
  • Basic comprehension of Total Ion Chromatogram (TIC) analysis
NEXT STEPS
  • Research the principles of Gas Chromatography and its applications
  • Study the functioning of Mass Spectrometers, focusing on ionization methods
  • Learn about the interpretation of Total Ion Chromatograms in quantitative analysis
  • Explore advanced techniques in mass spectrometry for fragment detection
USEFUL FOR

Researchers, chemists, and laboratory technicians involved in analytical chemistry, particularly those working with gas chromatography and mass spectrometry for molecular detection and quantification.

BBChem42
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So I am working on theoretical project that challenges my group to detect and quantify a certain molecule in a sample. For the detection and quantification we have chosen to work with a gas chromatography-mass spectroscopy. However I am finding difficulties in how this device is able to detect amounts of certain fragments. I am aware that there is a mass analyser that can detect fragments with a certain mass/charge ratio but what detects the amount of every fragment? Looking for a good source to read into this detection method or just straight answers here. Thanks
 
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Welcome to PF.

Can you give us some links to the reading you've been doing so far about how those types of instruments work? Thanks.
 
“TOTAL ION CHROMATOGRAM”

Good search term
 
Measuring current and counting electrons are basically the same thing.
 
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BBChem42 said:
So I am working on theoretical project that challenges my group to detect and quantify a certain molecule in a sample. For the detection and quantification we have chosen to work with a gas chromatography-mass spectroscopy. However I am finding difficulties in how this device is able to detect amounts of certain fragments. I am aware that there is a mass analyser that can detect fragments with a certain mass/charge ratio but what detects the amount of every fragment? Looking for a good source to read into this detection method or just straight answers here. Thanks
How does your mass spectrometer separate the various fragments after ionization?
 

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