How long does MCH stay elevated after beginning folate/b12 supplimentation?

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SUMMARY

The discussion centers on the duration for MCH (Mean Corpuscular Hemoglobin) levels to normalize after initiating folate and B12 supplementation in patients with deficiencies. A study involving 60 patients indicated that hematologic parameters, including MCH, significantly improved over a 90-day period following treatment. Reticulocytosis, an early indicator of treatment response, typically occurs within 5 to 10 days. The study also highlighted that both oral and intramuscular B12 supplementation yielded similar results, although oral treatment may be effective in certain cases of pernicious anemia.

PREREQUISITES
  • Understanding of hematologic parameters, specifically MCH and reticulocytosis.
  • Knowledge of vitamin B12 and folate supplementation protocols.
  • Familiarity with the implications of pernicious anemia and gastric intrinsic factor.
  • Awareness of clinical study methodologies and patient treatment outcomes.
NEXT STEPS
  • Research the mechanisms of reticulocytosis in response to B12 supplementation.
  • Explore different B12 supplementation methods and their efficacy in treating deficiencies.
  • Investigate the role of folate in conjunction with B12 for hematologic health.
  • Review clinical guidelines for managing pernicious anemia and alternative treatment options.
USEFUL FOR

This discussion is beneficial for healthcare professionals, hematologists, nutritionists, and anyone involved in the treatment and management of vitamin B12 and folate deficiencies.

ihaveabutt
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In iron and/or b12 deficiency, once levels of b12 and Ferritin have normalized.
How long does it take for the MCH to return to normal ranges?
 
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ihaveabutt said:
In iron and/or b12 deficiency, once levels of b12 and Ferritin have normalized.
How long does it take for the MCH to return to normal ranges?

In this study of 60 patients with B12 deficiency, all hematologic parameters significantly improved from baseline over a 90 day interval. Reticulocytosis is an early sign of treatment effect which should appear between 5 and 10 days. This study compared oral and intramuscular B12 and found no significant difference. However, in pernicious anemia, a deficiency or lack of gastric intrinsic factor would normally preclude oral treatment, but oral therapy can be effective in some cases with certain preparations of B12 or in high doses.

www.ncbi.nlm.nih.gov/pubmed/14749150

www.keckmedicalcenterofusc.org/condition/document/96607
 
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