How quickly does E.coli gain resistance against antibiotics?

In summary, bacteria, particularly E.coli, can develop resistance to antibiotics through various mechanisms, including spontaneous or induced genetic mutation and horizontal gene transfer via conjugation, transduction, or transformation. While many antibiotic resistance genes are carried on transmissible plasmids, mutations in the bacterial genomic DNA can also confer resistance. The speed at which resistance develops varies and can occur within a day, depending on the specific antibiotic and bacteria being studied.
  • #1
Eagle9
238
10
As well-known, the bacteria (particularly E.coli) can gain the resistance against antibiotics. In Wikipedia its mechanism is written:
It may take the form of a spontaneous or induced genetic mutation, or the acquisition of resistance genes from other bacterial species by horizontal gene transfer via conjugation, transduction, or transformation. Many antibiotic resistance genes reside on transmissible plasmids, facilitating their transfer.
I would like to know:
1) Are there any OTHER mechanisms for gaining the resistance? Can the bacteria gain resistance when it has got antibiotic, LB broth in medium and nothing more? In other words, we have got only one species of bacteria (E.coli in this case), the antibiotic and LB broth, but there are no other species of bacteria that can give/lend plasmids to E.coli. So, can E.coli gain resistance in this situation?
2) How quickly do the bacteria generally gain the resistance? Can it happen during several hours or more time is needed? :rolleyes:
 
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  • #2
1. As stated in the wikipedia article, spontaneous or induced genetic mutation offer a pathway to resistance that does not involve horizontal gene transfer. Such mutations may prevent the antibiotic from binding its target or increase efflux of the antibiotic from the bacterium.

2. For this and the above question, you may find the following article useful:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534735/
 
  • #3
Ygggdrasil
1. As stated in the wikipedia article, spontaneous or induced genetic mutation offer a pathway to resistance that does not involve horizontal gene transfer. Such mutations may prevent the antibiotic from binding its target or increase efflux of the antibiotic from the bacterium.
And such mutation comes from plasmids? :rolleyes:

For this and the above question, you may find the following article useful:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534735/
So long! :eek: By the way I am earning my master's degree now and I have got very similar thesis. In some experiments we observed the gained resistance (but this happened during 1 day) for E.coli and I wanted to know where does it comes from :smile:
 
  • #4
Eagle9 said:
YgggdrasilAnd such mutation comes from plasmids? :rolleyes:

No, such mutation can occur in the genomic DNA. Check the Nature Genetics paper for examples (e.g. for trimethoprim resistance, mutations emerge in the DHFR gene on the bacterial chromosome).
 
  • #5


I can provide some information on the topic of antibiotic resistance in E.coli. Firstly, it is important to note that E.coli, like other bacteria, can develop resistance to antibiotics through various mechanisms. These mechanisms include spontaneous or induced genetic mutations, as well as the acquisition of resistance genes from other bacterial species through horizontal gene transfer.

To address your first question, there are indeed other mechanisms through which E.coli can gain resistance to antibiotics. For example, some bacteria can develop resistance through changes in their cell membrane or cell wall, making it more difficult for antibiotics to enter and kill them. Additionally, some bacteria can produce enzymes that can inactivate certain antibiotics.

Regarding your second question, the rate at which E.coli gains resistance to antibiotics can vary depending on the specific antibiotic and the conditions under which the bacteria are grown. In general, bacteria can develop resistance relatively quickly, sometimes within a few hours or days. However, this can also depend on factors such as the concentration of the antibiotic, the frequency of exposure to the antibiotic, and the genetic makeup of the bacteria.

In conclusion, E.coli, like other bacteria, can develop resistance to antibiotics through various mechanisms. These mechanisms can occur even in the absence of other bacterial species that can transfer resistance genes. The rate at which resistance develops can vary, but it can happen relatively quickly in some cases.
 

Related to How quickly does E.coli gain resistance against antibiotics?

What is E.coli and why is it important to study its resistance against antibiotics?

E.coli, short for Escherichia coli, is a type of bacteria commonly found in the gut of humans and animals. It is important to study its resistance against antibiotics because E.coli is a major cause of foodborne illnesses and infections, and its resistance to antibiotics can make treatment more difficult and lead to more severe infections.

How quickly can E.coli develop resistance against antibiotics?

The rate at which E.coli develops resistance to antibiotics varies depending on the specific antibiotic and the environment it is exposed to. In general, it can take as little as a few weeks for E.coli to develop resistance.

What factors contribute to the development of antibiotic resistance in E.coli?

The main factor contributing to the development of antibiotic resistance in E.coli is the overuse and misuse of antibiotics. When antibiotics are used too frequently or inappropriately, bacteria like E.coli can adapt and develop resistance to them. Additionally, the natural ability of bacteria to mutate and share genetic material also plays a role in the development of antibiotic resistance.

How does E.coli gain resistance against antibiotics?

E.coli can gain resistance against antibiotics in several ways. One way is through mutations in its genetic material, which can alter the structure of the bacteria and make it resistant to certain antibiotics. Another way is through the acquisition of resistance genes from other bacteria through a process called horizontal gene transfer.

Can E.coli lose its resistance to antibiotics?

Yes, it is possible for E.coli to lose its resistance to antibiotics. This can happen when the selective pressure of antibiotics is removed or reduced, allowing susceptible bacteria to outcompete the resistant ones. However, it is important to note that the loss of resistance can also be temporary and bacteria may regain resistance over time.

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