To calculate the sum \( S_n = \sum_{k=1}^n \frac{2k+1-n}{(k+1)^2(n-k)^2+1} \), one approach involves simplifying the expression in the summation. The numerator \( 2k + 1 - n \) can be analyzed in relation to the denominator, which consists of quadratic terms in \( k \) and \( n \). Evaluating specific values of \( n \) can provide insights into the behavior of the sum. The discussion emphasizes the importance of algebraic manipulation and potentially applying limits or series convergence techniques. Overall, the calculation of \( S_n \) requires careful consideration of both the numerator and denominator's interactions.