How would I find the reversal potential for conductance

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SUMMARY

The discussion focuses on calculating the reversal potential for a membrane that is equally permeable to sodium (Na+), potassium (K+), and chloride (Cl-). Participants confirm that the Nernst equation is the appropriate tool for this calculation. The specific ion concentrations provided are Na+ at 20mM inside and 140mM outside, K+ at 130mM inside and 5mM outside, and Cl- at 5mM inside and 150mM outside. The reversal potential can be determined by applying the Nernst equation for each ion and then averaging the results based on their permeability.

PREREQUISITES
  • Understanding of the Nernst equation
  • Knowledge of ion concentration gradients
  • Familiarity with membrane permeability concepts
  • Basic principles of electrochemical gradients
NEXT STEPS
  • Research the Nernst equation and its applications in neurophysiology
  • Study the Goldman equation for calculating reversal potentials in multiple ion systems
  • Explore the concept of ion permeability ratios and their impact on membrane potential
  • Investigate the physiological roles of Na+, K+, and Cl- in cellular signaling
USEFUL FOR

Students and professionals in physiology, biophysics, and neuroscience, particularly those interested in cellular membrane dynamics and ion channel behavior.

madbeemer
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I know the following
ion/inside cell/outside cell
Cl- 5mM 150 mM
K+ 130mM 5mM
Na+ 20mM 140mM
Ca2+ 10^-4mM 2mM

How would I find the reversal potential for conductance equally permeable to sodium and potassium?
How do I find the reversal potential for a conductance equally permeable to sodium, potassium, and chlorine?
 
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Do you use nernst? lol Help please. Not sure how to go about this.
 

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