I have interviewed successfully for several jobs requiring PhD's. In the three successes I tailored my presentation to fit the job requirements.
For example during the on site interview process at Stanford Research Institute (SRI International), I was given a tour of the entire facility where I could question other scientists and engineers. I also had personal interviews with most of the principle researchers where I learned even more about the goals and conduct of the laboratories, how experiments are structured and funded, what data and resources could be shared, etc.
By the time I gave my presentation to the staff I had (mentally) tailored my talk to the needs and requirements of the laboratory. The Q&A following my lecture became a brainstorming session where we modified a computer network I had help design while at NASA to a lower budget series of shared networks suitable to the different research environment. I was able to judge from the earlier interviews the subjects of most interest. When I began work at SRI we essentially implemented the networks outlined in my talk with excellent results.
Not to sound manipulative but professional, by listening closely during numerous interviews I was able to pitch my lecture to the audience level. Parts of the presentation reached the computer science PhD's with appropriate explanations for mathematicians and linguists. I found that clear concise English coupled with clean white board diagrams made for a successful lecture. In a nutshell: adapt to the environment.