Is it certain that CMBR originates from the 5% of ordinary matter?

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Is this cold spot any cause for concern for the standard model?
It does seem to suggest at least that the Universe is not quite as isotropic and homogeneous as first thought. Do CMBR hot spots and cold spots correlate at all with galaxy super clusters and super voids and if so what is the cause of the correlation?

http://en.wikipedia.org/wiki/CMB_cold_spot

http://news.yahoo.com/scientists-discuss-universes-strange-dense-spot-wednesday-watch-151311146.html

http://en.wikipedia.org/wiki/Large-scale_structure_of_the_universe#Large-scale_structure

http://en.wikipedia.org/wiki/Huge-LQG
 
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The probability of finding a deviation at least as high in Gaussian simulations was found to be 1.85%.
Interesting, but not a serious issue if that number does not change.

Do CMBR hot spots and cold spots correlate at all with galaxy super clusters and super voids and if so what is the cause of the correlation?
Integrated Sachs-Wolfe effect, as mentioned in the article. The original hot/cold regions come from matter so far away that we don't see the galaxies that formed out of this - their light did not reach us yet, and probably won't if the expansion of the universe keeps accelerating.