For next week's journal club I will be presenting "Neural Activity in Speech-Sensitive Auditory Cortex During Silence", Hunter et al. PNAS Jan 3, 2006 http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16371474 Along with this paper, I would also like to present "Where the Imaginal Appears Real: A positron Emission Tomography Study of Auditory Hallucinations" Szechtman et al PNAS Feb 1998 http://www.pubmedcentral.gov/articlerender.fcgi?artid=19222 The papers are both pretty short and the more recent paper makes more sense in context of the older paper. Auditory hallucinations are a major feature of schizophrenia and previous studies have shown that "imagined" hearing and hallucinations have similar activational patterns in the brain. The older paper tries to discern between the "imagined" hearing, hallucinations, and external hearing using PET scans. The more recent paper argues that there is a baseline activation of the anterior cingulate cortex (the area activated during hallucinations) that can be activated even when there is silence. They hypothesize that it is the changes from normal baseline activity that cause the auditory hallucinations.