Limb Regeneration and Functional Recovery in adult Xenopus laevis

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SUMMARY

Adult Xenopus laevis successfully regrew amputated hind legs with full functional recovery after a 24-hour exposure to a multidrug, pro-regenerative treatment administered via a wearable bioreactor. This treatment led to significant tissue repatterning and the regeneration of complex structures, including skin, bone, vasculature, and nerves. Sensorimotor pathways were restored to preinjury levels, confirming the reestablishment of afferent sensory nerve fibers and neuromuscular tissue interfaces. The study demonstrates the potential for advanced regenerative therapies in amphibians.

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Amputated hind legs were sucessfully regrown and functional in adult frogs.


"Here, we demonstrate long-term (18 months) regrowth, marked tissue repatterning, and functional restoration of an amputated X. laevis hindlimb following a 24-hour exposure to a multidrug, pro-regenerative treatment delivered by a wearable bioreactor. Regenerated tissues composed of skin, bone, vasculature, and nerves significantly exceeded the complexity and sensorimotor capacities of untreated and control animals’ hypomorphic spikes.
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...we determined that sensorimotor pathways were functionally restored to preinjury levels in the animals exposed to the full treatment condition, indicating reestablishment of afferent sensory nerve fibers and neuromuscular tissue interfaces.


Popular article:
https://www.livescience.com/frogs-regrow-amputated-legs-in-lab

Technical article:
https://www.science.org/doi/10.1126/sciadv.abj2164
 
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People have wanted to do this at least since I was in grad school, in the 1980's.
 
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