Mammalian Enteral Ventilation - a new way to breathe

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SUMMARY

Mammalian enteral ventilation has been successfully demonstrated as a method for blood oxygenation through the lower intestinal tract in both mice and pigs. This innovative approach utilizes intra-rectal delivery of conjugated perfluorocarbon, a liquid form of oxygen, to provide temporary respiratory assistance. The technique draws inspiration from loaches, which utilize intestinal air breathing, and shows significant potential for treating severe respiratory failure in humans. The findings are detailed in a recent publication in Cell.

PREREQUISITES
  • Understanding of respiratory physiology
  • Familiarity with perfluorocarbon compounds
  • Knowledge of enteral ventilation techniques
  • Basic principles of animal model research
NEXT STEPS
  • Research the clinical applications of conjugated perfluorocarbon in liquid ventilation
  • Explore the mechanisms of intestinal air breathing in loaches
  • Investigate the potential of enteral ventilation in human respiratory therapies
  • Study the ethical considerations of using animal models in respiratory research
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Medical researchers, respiratory therapists, and clinicians interested in innovative treatments for respiratory failure will benefit from this discussion.

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From: https://www.cell.com/med/fulltext/S2666-6340(21)00153-7?utm_source=EA

Blood oxygenation through the lower intestinal tract is demonstrated in both mice and pigs. It is hoped this wiil work for those Humans that need temporary assistance with respiratory function.

Inspired by organisms such as loaches that use intestinal air breathing, we show the effectiveness of an enteral ventilation approach in attaining systemic oxygenation in both rodent and porcine models. Intra-rectal delivery of a liquid form of O2 known as conjugated perfluorocarbon, a compound historically used in clinics for liquid ventilation through airway administration, is highly tolerable and efficacious in ameliorating severe respiratory failure.
 
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