Marburg outbreak in Rwanda

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Discussion Overview

The discussion revolves around the recent Marburg virus outbreak in Rwanda, focusing on the implications of a lower-than-expected case fatality rate and the factors contributing to this outcome. Participants explore the historical context of Marburg outbreaks, healthcare responses, and cultural practices affecting transmission. The conversation includes reflections on the evolution of healthcare systems in response to viral outbreaks.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants note that the current case fatality rate of 22.7% in Rwanda is among the lowest ever recorded for a Marburg outbreak, suggesting improvements in healthcare responses.
  • Others propose that better care, developed from lessons learned during the Covid pandemic, is a significant factor in the improved outcomes.
  • One participant recalls that funeral customs, where individuals wash and dress the deceased, have historically contributed to the spread of similar viruses, including Ebola.
  • Another participant emphasizes the importance of rapid response and early treatment in increasing survival rates, referencing fluid loss as a critical factor in mortality.
  • Concerns are raised about the historical context of high mortality rates associated with hemorrhagic fevers and the potential for international spread, although it is noted that the rapid decline in health of infected individuals may limit transmission opportunities.
  • There is mention of the zoonotic nature of outbreaks and the challenges in estimating mortality rates due to low case numbers.

Areas of Agreement / Disagreement

Participants express a mix of viewpoints, with some agreeing on the role of improved healthcare in reducing mortality rates, while others highlight the historical context and cultural practices that may still pose risks. The discussion remains unresolved regarding the overall implications of the outbreak and the effectiveness of current responses.

Contextual Notes

Participants reference various factors influencing the outbreak's dynamics, including healthcare adaptations, cultural practices, and historical mortality rates. There is an acknowledgment of the complexity surrounding the transmission and management of the virus, with no consensus on the implications of the current situation.

Astronuc
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An 'unprecedented' good news story about a potentially deadly viral outbreak
https://www.npr.org/sections/goats-...marburg-outbreak-rwanda-unprecedented-success
Marburg virus is notorious for its killing ability. In past outbreaks, as many as 9 out of 10 patients have died from the disease. And there are no approved vaccines or medications.

That was the grim situation in Rwanda just over a month ago, when officials made the announcement that nobody wants to make: The country was in the midst of its first Marburg outbreak.

Now those same Rwandan officials have better news to share. Remarkably better.

“We are at a case fatality rate of 22.7% — probably among the lowest ever recorded [for a Marburg outbreak],” said Dr. Yvan Butera, the Rwandan Minister of State for Health at a press conference hosted by Africa Centers for Disease Control and Prevention on Thursday.

Related thread
https://www.physicsforums.com/threads/marburg-case-in-gueckedou-prefecture-guinea-w-africa.1005996/
 
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jedishrfu said:
But why? Are people somehow adapting to the disease?
From the article, it appears better care is the reason. And better care developed from things learned during the Covid pandemic. So I would say it was the healthcare system that adapted.

Also mentioned in the article was that during the very first Marburg outbreak, in Germany in 1967, the mortality rate was 23%.
 
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I recall one of the issues was funeral customs in some areas where people washed, dressed, and laid hands on the deceased to say goodbye.
 
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jedishrfu said:
I recall one of the issues was funeral customs in some areas where people washed, dressed, and laid hands on the deceased to say goodbye.
Yes, that was an issue with Ebola as well.

I think a more rapid response with those who contract the virus and better health care have lead to more people surviving.

In the Wikipedia article on Ebola, another hemorrhagic virus, it mentions:
Death is often due to shock from fluid loss, and typically occurs between six and 16 days after the first symptoms appear. Early treatment of symptoms increases the survival rate considerably compared to late start.
Fluid loss comes from vomiting and diarrhea, and eventually bleeding. An ill patients may be too ill or weak to drink, so IV solutions would be necessary.

https://en.wikipedia.org/wiki/Ebola

https://en.wikipedia.org/wiki/Marburg_virus
https://en.wikipedia.org/wiki/Marburg_virus_disease

There are vaccines for the Ebola virus (or orthoebolavirus), but not for Marburg, yet.
 
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Astronuc said:
I'm not sure whether this good news. I remember when these haemorrhagic fevers started being reported and the fear generated by the very high mortality rate seen. There was a real concern of international spread, which would have been devastating, luckily it didn't happen.

Apparently while the virus is readily transmitted by physical contact, people infected become profoundly ill very quickly, this in fact has a massive effect on the opportunity of transmission. The high mortality rate and slow recovery effectively localised any spread. It seems that each new outbreak is the result of zoonotic spread and the low numbers make any estimates of a mortality rate unreliable.
 
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