Dear all ! Does anyone have experience with methanotrophic bacteria ? The background of my question: I am trying to explore a new pathway for the reaction methane to methanol. One can basically think of two approaches: a) chemically via classic catalysts, b) biologically via enzymes or bacteria. Methanotrophic bacteria contain an enzyme called oxygenase, and they seem to be most promising when it comes to a biocatalytic conversion of methane to methanol. Research has been done for almost 100 years on that topic, so far no one has implemented an economically feasible process for making methanol directly from methane. The main problem is the low yield (below 10 %).