Mitosis, apoptosis and necrosis

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In summary, the decision for a human cell to divide mitotically is based on a variety of factors including density-dependent growth, secreted factors, and regulatory processes such as contact inhibition. This decision is not always triggered by cell death events such as apoptosis and necrosis, but rather by the availability of space and other external factors. The provided resources offer more detailed explanations on how cells divide and respond to different stimuli.
  • #1
mktsgm
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How and when does a human cell decides to divide mitotically. How it responds to apoptosis and necrosis? Do these cell deaths trigger mitosis so that the cellular count is maintained in the body?
 
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  • #3
Thanks four your referrals. They explain nicely how cells divide.

But my main question is when the cells decide to divide.

Suppose there is an apoptotic cascade in a tissue. Or a bout of necrosis. Now the cellular population would have come down in the tissue. Will the left over cells of that tissue decide to divide in mitosis? Or will it wait for some other trigger?
 
  • #4
This is not a complete answer, but many cells exhibit density-dependent growth. If there is space around the cell, cells will keep on growing and dividing. However, once their niche begins to fill and the density of cells rise, the growth rate slows. This is due to some secreted factors that cells produce to keep each others' growth in check (as cell density rises, so does the concentration of these factors) and regulatory processes such as contact inhibition where cell-cell contact inhibits growth and replication.
 

What is mitosis?

Mitosis is the process of cell division in which one cell divides into two identical daughter cells. This process is important for growth, repair, and maintenance of an organism.

What is apoptosis?

Apoptosis is a programmed cell death that occurs when a cell is no longer needed or has become damaged beyond repair. It is a natural process that helps maintain balance and proper functioning of the body's cells.

What is necrosis?

Necrosis is the death of cells or tissues due to injury, infection, or lack of blood supply. Unlike apoptosis, necrosis is not a programmed process and can be detrimental to the overall health of an organism.

What are the differences between mitosis and apoptosis?

Mitosis is a process of cell division, while apoptosis is a process of programmed cell death. Mitosis results in two identical daughter cells, while apoptosis results in the removal of damaged or unnecessary cells. Additionally, mitosis is a controlled process, whereas apoptosis is triggered by various internal and external factors.

What are some examples of diseases or disorders associated with abnormal cell death?

Some examples include cancer, which is caused by uncontrolled cell growth, and neurodegenerative diseases, such as Alzheimer's and Parkinson's, which are caused by the death of brain cells. Autoimmune diseases, infections, and heart diseases can also be linked to abnormal cell death.

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