If the moon was somehow cleanly removed without showering the Earth with fragments, then this would have a slight effect on the Earth's orbit but no immediate effect on its rotation. The effect on the Earth's orbit can be understood by considering the Earth and moon as a combined rotating system; if the moon is suddenly removed, the overall momentum of that system is changed by the momentum of the moon in its orbit around the Earth.
Using figures from the internet, I make it that the mass of the moon is very roughly about 1/80th of that of the Earth, and the relative velocity of the moon in its orbit about the Earth is about 1/30th of that of the Earth about the sun, so the fractional change in momentum of the Earth in its orbit would be about 1/(80*30) = 1/2400. If the change in momentum were aligned forward or backwards along the orbit to maximize the effect on the velocity, then the fractional change in kinetic energy in the orbit would be proportional to the square of this, that is around 1 part in 6 million.
Another effect of losing the moon would be that ocean tides would be much smaller (something like only 1/3 of the amplitude), as they would only be due to the sun. They would also be locked into a repeating daily cycle with some variations over a yearly cycle instead of changing in time of day and amplitude over a monthly cycle.
The reduction in the tides would also mean in the very long term that the rate of slowing of the Earth's rotation would be reduced.