Nuclear knockout reactions - why does a proton knockout a neutron?

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SUMMARY

The discussion centers on the nuclear knockout reactions involved in the synthesis of fluorodeoxyglucose (FDG), specifically the interaction between O-18 and accelerated protons. During this process, a proton collides with O-18, resulting in the ejection of a neutron rather than another proton due to the specific energy dynamics of the reaction. The formation of F-18 leads to a temporary positively charged state, which quickly captures an electron from the environment to maintain charge balance. This highlights the importance of understanding nuclear reactions in medical imaging applications.

PREREQUISITES
  • Nuclear physics principles, particularly regarding proton and neutron interactions
  • Understanding of isotopes, specifically O-18 and F-18
  • Basic knowledge of particle acceleration techniques
  • Familiarity with charge balance in chemical reactions
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  • Research the mechanics of nuclear knockout reactions in detail
  • Study the synthesis processes of isotopes used in PET imaging
  • Explore the role of particle accelerators in isotope production
  • Learn about charge balance and electron capture in chemical reactions
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Physicists, chemists, medical imaging professionals, and anyone involved in the production of radiopharmaceuticals for diagnostic purposes.

skh149
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Questions about the formation of F-18 from O-18; why a neutron is selectively knocked out, how do the charges balance out
I am studying the synthesis of FDG for a job interview. The process of creating the F-18 used in FDG involves the collision of O-18 with an accelerated proton -- the proton kicks out a neutron and everything adds up. I am just wondering why a neutron is specifically knocked out, why wouldn't another proton be kicked out instead? Is it 50/50 but the proton exchange is essentially no change at all? Thanks for any replies.

Bonus question: I might make this a separate post. But when the F-18 is formed it would be positively charged. I believe it quickly turns into an anion but still, the charges would not be balanced in the system (correct?). Would the solution have an overall electrical charge? Are electrons stripped from the environment? (In chemistry you usually can't just add a charged particle to a solution without its opposite charge. I.e. Na+Cl- )
 
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O-18 + p -> O-18 + p is a possible (and even likely) reaction, it's just not the reaction people are interested in. You can't control what reaction happens but you can bombard oxygen (or water) with enough protons and then separate out fluorine.

It's an ion briefly but it will quickly capture a random electron from the environment.
Your proton beam is a source of positive charges but grounding the equipment keeps it neutral.
 

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