A single photon is sufficient to isomerize retinal in a rhodopsin molecule, thereby activating it. Individual rod cells in the retina can respond to just one photon. However, while the activation of rhodopsin by a single photon is crucial for initiating the visual process, downstream neurons in the visual pathway may require signals from multiple rod cells to trigger a nerve impulse to the brain. This indicates a complex interplay between the initial photon detection and the subsequent neural processing involved in vision.