Makes navigation a lot easier. Stupid question really.
If you have one ship aligned so the top is facing the top of the galaxy and one ship aligned with the top facing the bottom of the galaxy, and then provided them with a vertical elevation and a horizontal one, they would end up flying away in a mirror image from each other (shall we say 10 degrees starboard and 10 degrees ascent). For example, one may move up towards the top of the galaxy and right, but the other would mirror this moving down towards the bottom of the galaxy and left (from a single viewpoint). The ships would think they are going the correct way from their point of view. A simple gyro would do the job if you aligned it with the galaxy fairly well. No matter what you did within the ship it would always be true to the galaxy allowing perfectly good navigation (at least to some extent).
All charts of the space could be standardised, if a ship was to invert itself in flight (fly upside down) you would have to flip the chart, failure to do so would be a major problem.