Note that the degree of the polynomial is even, if there exists one real root, then there must exist either two roots of multiplicity one or one root of multiplicity two. Therefore we may write:
$x^4+px^3+2x^2+qx+1=(x^2+ax\pm1)(x^2+bx\pm1)$ for some real $a,\,b$.
We now split the problem into two cases:
Case I: $x^4+px^3+2x^2+qx+1=(x^2+ax+1)(x^2+bx+1)$
The coefficient of $x^2$ from the RHS equals to $2+ab$, setting this equals to 2 gives $ab=0$. WLOG, let $a=0$, then the factorization boils down to $(x^2+1)(x^2+bx+1)$. Since $x^2+1$ has no real rots, $x^2+bx+1$ must have one, so $b^2\ge 4$. Finally, expanding out the RHS and comparing coefficients gives $p=q=b$, so $p^2+q^2=2b^2\ge2(4)=8$, as desired.
Case II: $x^4+px^3+2x^2+qx+1=(x^2+ax-1)(x^2+bx-1)$
The coefficient of $x^2$ from the RHS equals to $-2+ab$, setting this equals to 2 gives $ab=4$. WLOG, let $p=a+b$, and $p=-(a+b)$. This means that $p^2+q^2=2(a+b)^2=2(a^2+b^2)+4ab=2(a^2+b^2)+16$ and since $a^2+b^2\ge 0$, the entire expression is $\ge 16$, which obviously makes the expression greater than 8, as desired.
Finally, note that when both $x^2$ coefficients are negated, the only aspect of the problem that differs is the sign of the $ax$ and $bx$ coefficients. Running through the steps shown above, it can be seen that this does not affect the value of $p^2+q^2$.
Hence all cases are covered, and so we're done.