Question about blood transfusion

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Discussion Overview

The discussion revolves around the compatibility of blood transfusions, specifically addressing the differences between male and female blood, the implications of hormonal differences, and considerations for patients requiring frequent transfusions. It touches on both theoretical and practical aspects of blood transfusion practices.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • The original poster questions why a woman can donate blood to a man despite perceived differences in blood composition, such as hormones and red cell concentration.
  • Some participants note that whole blood is rarely transfused, as it is typically separated into components like red blood cells and plasma.
  • One participant argues that hormones, such as estrogen, do not persist long in the body and thus should not pose a significant issue in transfusions.
  • Another participant humorously suggests that if hormones were a significant concern, many transfusions would be contaminated with epinephrine from the needle insertion process.
  • A later reply highlights the risks for patients with thalassemias who require frequent transfusions, specifically mentioning the potential for iron overload and its effects on organs.
  • Additional trivia is provided regarding canine and feline blood transfusions, noting differences in antibody presence and the need for crossmatching in different species.

Areas of Agreement / Disagreement

Participants express differing views on the relevance of hormonal differences in blood transfusions, and while some technical aspects of blood transfusion practices are acknowledged, there is no consensus on the significance of gender in blood donation compatibility.

Contextual Notes

The discussion includes assumptions about the effects of hormones in blood and the specific medical considerations for patients requiring frequent transfusions, which may not be fully explored or resolved.

fluidistic
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Althought I understand that a rhesus A+ can donate blood to a rhesus A+, I don't really understand why a woman can donate blood to a man despite the compatibility of the blood group.
As far as I know there are a lot of differences between women and men's blood. For example hormones, the concentration of red cells and platelets, etc.

What about people who need a blood transfusion by week? Do physicians/nurses care about transfusing blood to a patient from a patient of the same sex? Or they don't even look at that?
 
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Whole blood is rarely transferred blood is spun down and separated out into red blood cells, plasma etc

Hormones don't last that long in your body - any extra eostrogen will soon be destroyed
 
mgb_phys said:
Whole blood is rarely transferred blood is spun down and separated out into red blood cells, plasma etc

Hormones don't last that long in your body - any extra eostrogen will soon be destroyed

I see, thanks.
 
If hormones were a problem - a lot of blood transfusions would be contaminated with epinephrine from somebody sticking a big needle in you!
 
From the OP: "What about people who need a blood transfusion by week?"

Folks who have thalassemias (heritable blood disorders) needing frequent transfusions are indeed at risk (and carefully monitored) for iron overload which can be damaging to organs (heart, liver, etc.).

A little side-topic trivia:
Canine blood allows dogs to receive one "free" transfusion without crossmatching because they don't have naturally occurring antibodies against all the other canine blood types. After the first transfusion, however, dogs can develop those antibodies and must be crossmatched thereafter. Cats do have antibodies against the blood types they are lacking and should be carefully matched and transfused from the start. And then there are the multiple blood types of horses...:-j
 

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