I don't see the attachment.brake4country said:But, here is the reaction that I have determined so far, attached below.
This shouldn't matter. Just treat the organolithium compound as approximately R-Li+, with R = vinyl, and just do the same type of arrow-pushing you'd do with, e.g., butyllithium.brake4country said:I am having a hard time understanding how it attaches to the carbonyl since it is sp2 hybridized.
The reaction mechanism for ketone and vinyl lithium is a nucleophilic addition reaction. The vinyl lithium acts as the nucleophile, attacking the carbonyl carbon of the ketone and forming an intermediate alkoxide. This intermediate then undergoes protonation and elimination to form the final product, an alkene.
Vinyl lithium acts as the nucleophile in this reaction. It attacks the carbonyl carbon of the ketone, forming an intermediate alkoxide. This intermediate then undergoes protonation and elimination to form an alkene.
Ketones and vinyl lithium react through a nucleophilic addition reaction. The vinyl lithium acts as the nucleophile, attacking the carbonyl carbon of the ketone and forming an intermediate alkoxide. This intermediate then undergoes protonation and elimination to form the final product, an alkene.
The reaction between ketone and vinyl lithium requires a polar, aprotic solvent such as diethyl ether or THF. It also requires the presence of a strong base, usually lithium diisopropylamide (LDA), to generate the reactive vinyl lithium species.
The major products of the reaction between ketone and vinyl lithium are an alkoxide intermediate and an alkene final product. The alkoxide intermediate is formed through the nucleophilic addition of vinyl lithium to the ketone, while the alkene is formed through protonation and elimination of the intermediate. The exact product formed will depend on the specific ketone and vinyl lithium reagents used.