Because of results like the Stone-von Neumann theorem. In non-relativistic QM, this theorem asserts that any irreducible unitary realization of the (integrated form of the) canonical commutation relations on a complex Hilbert space ##H## (in principle, not necessarily separable) is unitarily equivalent to the standard realization in the separable space ##L^{2}(R^{3})##, i.e., only in a separable space you can get one such irreducible unitary realizations. Similar results hold for the representation theory of the Poincaré group in relativistic QM.