The May 20, 2016 issue of Science, p876-7, "Tracking how humans evolve in real time," subtitled, "Analyses of thousands of sequenced genomes show changes in as little as a generation," uses the term "singletons" in the 4th paragraph: "...single-base changes...or singletons..." My limited understanding presumes that a "single-base" change is one base in an allele. I cannot find a single reference on the net or in the many papers in my files on the subject of genes or genetics which use the term "singleton" by itself. I would like to be able to more broadly understand what the author is specifically intending or referring to with "singletons," and what other terms might be inclusive of the author's intentions in using "singletons," such as SNP. Or, are SNPs distinctly separate from anything relevant to "singletons?" Are "singletons" synonymous or related to "point mutations?" I believe that with most forms of science, the terminology is exponentially accelerating beyond any hope of an up to date glossary or reference, and we are enslaving ourselves in a form of ignorance by preferring single word definitions (that we can lay claim to for the enhancement of our status) of much that is actually complex, without providing a clear context. I hope I'm mistaken about that. Any links to relevant articles which will provide me with more understanding of "singletons" related to genes will also be appreciated.