SIR2: Could a Gene Extend Human Lifespan 6x?

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SUMMARY

The discussion centers on the SIR2 gene and its potential impact on human lifespan, specifically the hypothesis that its exclusion could extend lifespan by six times, as observed in certain animal models like worms. Participants clarify that the SIRone gene, which suppresses longevity, allows deficient cells to divide indefinitely while remaining normal and cancer-free. The conversation references research conducted on mice cells, highlighting the significance of the SIRone gene in longevity studies.

PREREQUISITES
  • Understanding of genetic terminology, specifically regarding longevity genes.
  • Familiarity with cellular biology concepts, particularly cell division and cancer biology.
  • Knowledge of model organisms in genetic research, such as worms and mice.
  • Basic comprehension of gene expression and suppression mechanisms.
NEXT STEPS
  • Research the role of the SIR2 gene in aging and longevity studies.
  • Explore the implications of SIRone gene deficiency in cellular biology.
  • Investigate current findings on gene manipulation in mice and its effects on lifespan.
  • Learn about the methodologies used in longevity research, including genetic engineering techniques.
USEFUL FOR

Geneticists, biologists, researchers in aging and longevity studies, and anyone interested in the genetic factors influencing lifespan extension.

bioquest
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Could the exclusion of the SIR2 gene lengthen the human lifespan 6 times? it's been shown to lengthen lifespan like that in animals such as worms right?
 
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I think I misread/was thinking about the wrong gene

Apparently SIRone gene suppresses longevity and SIRone deficient cells divide indefinetly and appear normal/cancer free? Does anyone have any more information on this?
Is the correct name for the gene that suppresses longevity, and whose cells, when empty of the gene divide indefinetly and appear normal/cancer free the SIRone gene? I think they've done this in mice cells?
 
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Here's the website I found it on, after using google like 20 times to re-find the page

http://www.biotech-weblog.com/50226711/sirt1_gene_suppresses_longevity.php
 
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