I don't even know if this question can be salvaged into a reasonable topic, but I'll try (although I suspect that this topic is not allowed on these forums. I'll do my best to keep it professional):
Many natural products, such as cannabinoids and opioids, do have synthetic derivatives. In fact, the term "semi-synthetic" is often applied to these types of molecules. For example, morphine, extracted from poppy seeds, is used as a precursor in the industrial manufacture of hydromorphone.
However, it's much more complicated than just "adding oxygen" or "adding an inert gas" to the molecular structure. In fact, those terms are pretty meaningless--all reactions are organic reactions, and organic chemistry isn't as simple as adding A +B to make C. Of course, it becomes even more complicated in biological systems.
Deciding on an appropriate pharmaceutical derivative of a natural product is a complicated task: it involves first of all understanding how the original molecule interacts with different receptors in the body, the overall goal of the intended pharmaceutical, minimization of side effects and toxicity (relative to the intended dosage).
Overall, this is a cool field, but as you said, it's pretty clear you aren't a scientist or a chemist ;-)