The bradykinin hypothesis generated by a supercomputer AI

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SUMMARY

The discussion centers on the bradykinin hypothesis generated by a supercomputer AI, highlighting its role within a broader context of cytokine dysregulation in COVID-19. Key cytokines involved include IL-6 and components of the renin-angiotensin system, alongside various immune cells like T-cells and macrophages. While bradykinin contributes to symptoms such as leaky blood vessels, it is not the sole factor in severe COVID-19 manifestations, which also include clotting issues leading to strokes and heart attacks. The hypothesis generated by the supercomputer is a starting point for further research, emphasizing the need for a comprehensive understanding of cytokine interactions.

PREREQUISITES
  • Understanding of cytokine functions, particularly bradykinin and IL-6
  • Knowledge of the renin-angiotensin system and its role in immune responses
  • Familiarity with the pathophysiology of COVID-19, including clotting mechanisms
  • Basic comprehension of AI applications in scientific research
NEXT STEPS
  • Research the role of bradykinin in cytokine storms and its implications in COVID-19
  • Explore the interactions between IL-6 and the renin-angiotensin system
  • Investigate the mechanisms of clot formation in severe COVID-19 cases
  • Study advancements in AI applications for biomedical research and hypothesis generation
USEFUL FOR

This discussion is beneficial for immunologists, researchers in virology, and healthcare professionals focused on understanding the complexities of COVID-19 and the role of cytokines in disease progression.

kadiot
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First of all, the cytokine dysregulation ("storm" is such a loaded term, there are degrees - even storms have categories) involves not just bradykinin but a whole host of cytokines including IL-6 and the renin-angiotensin system. It also involves a whole lot of cells including T-cells, macrophages and endothelial cells. The reason why bradykinin is getting a lot of attention is because it seems to have a role ON TOP of all these other things going on. It is by no means the most important part of the response, but we do need to better define its role - along with all the other cytokines and immune processes going on. If it has a more significant role than in other diseases, then that is important and needs to be studied, but this story is by no means solved.

As an example, while bradykinin causes "leaky blood vessels," a major pathophysiologic manifestion of severe COVID-19 is CLOTS. This is what causes the strokes and some of the heart attacks. There are OTHER THINGS causing problems in COVID-19 and bradykinin is just ONE of them.

A supercomputer was used to generste the hypothesis, but the programming and inputs were made and interpreted by humans. I expect supercomputer AI to continue to get better in specialized tasks and act side-by-side with researchers/scientists.https://elemental.medium.com/a-supe...teresting-new-theory-has-emerged-31cb8eba9d63
 
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