It has nothing to do with size. It must refer to situations that can be observed many times under the same circumstances ("preparation") for the probability interpretation to make sense. The universe as a whole can neither be repeatedly prepared nor observed at all (according to the present cosmological model there's a horizon, behind which we can't look). So to associate a state with the universe as a whole is mute since you cannot check its validity by observation.
I don't think that there is any size restriction in the sense that for a sufficiently large system quantum theory breaks down. It's only hard to isolate large (macroscopic) systems sufficiently from interactions with the environment to prevent decoherence. Where possible mesoscopic and even macroscopic objects show quantum behavior, e.g., Zeilinger's bucky-ball double-slit experiment, entanglement of the phonon states of two macrocopic diamonds (at room temperature!), superfluidity of helium,...