Vitamin D Crucial to Activating Immune Defenses

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SUMMARY

Vitamin D is crucial for activating immune defenses, particularly in T cells, which require vitamin D receptors to respond to foreign pathogens. A clinical trial led by Dr. Mitsuyoshi Urashima demonstrated that children aged six to 15 taking vitamin D had a significantly lower incidence of flu compared to those on a placebo, indicating its effectiveness over vaccines. Additionally, research from the Intermountain Medical Center Heart Institute links vitamin D deficiency to an increased risk of coronary artery disease, suggesting that supplementation may mitigate this risk. Findings will be presented at the American College of Cardiology's 59th annual scientific session.

PREREQUISITES
  • Understanding of T cell immunology
  • Knowledge of vitamin D metabolism and its receptors
  • Familiarity with clinical trial methodologies
  • Awareness of cardiovascular disease risk factors
NEXT STEPS
  • Research the role of vitamin D receptors in T cell activation
  • Explore the impact of vitamin D supplementation on flu prevention
  • Investigate the relationship between vitamin D deficiency and cardiovascular disease
  • Review findings from the American College of Cardiology's 59th annual scientific session
USEFUL FOR

Healthcare professionals, immunologists, pediatricians, and anyone interested in the role of vitamin D in immune function and cardiovascular health.

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Professor Carsten Geisler from the Department of International Health, Immunology and Microbiology explains that "when a T cell is exposed to a foreign pathogen, it extends a signaling device or 'antenna' known as a vitamin D receptor, with which it searches for vitamin D. This means that the T cell must have vitamin D or activation of the cell will cease. If the T cells cannot find enough vitamin D in the blood, they won't even begin to mobilize. "
 
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Biology news on Phys.org
http://www.timesonline.co.uk/tol/news/uk/scotland/article7061778.ece

Only one in ten children, aged six to 15 years, taking the sunshine vitamin in a clinical trial came down with flu compared with one in five given a dummy tablet. Mitsuyoshi Urashima, the Japanese doctor who led the trial, told The Times that vitamin D was more effective than vaccines in preventing flu.

Vitamin D was found to be even more effective when the comparison left out children who were already given extra vitamin D by their parents, outside the trial. Taking the sunshine vitamin was then shown to reduce the risk of flu to a third of what it would otherwise be.
 
http://www.physorg.com/news187879711.html"

Researchers at the Intermountain Medical Center Heart Institute last fall demonstrated the link between vitamin D deficiency and increased risk for coronary artery disease. These new studies show that treating vitamin D deficiency with supplements may help to prevent or reduce a person's risk for cardiovascular disease and a host of other chronic conditions. They also establish what level of vitamin D further enhances that risk reduction.

Study findings will be presented at the American College of Cardiology 59th annual scientific session in Atlanta.
 
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