What are ions of molecules interacting with in vivo

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The discussion centers on the interactions of charged amino acids in vivo, specifically what these amino acids form salts with at physiological pH. It highlights that charged amino acids can interact with various biomolecules, including other amino acids, sugars, and fatty acids, depending on the presence of opposite charges. The conversation also notes that while most ions in solution exist as separated ions, exceptions like Mg2+ associating with nucleotide triphosphates (e.g., ATP) demonstrate stable interactions. Ultimately, the equilibrium conditions favor the ionic forms of ions such as potassium and amino acids in the cytosol.

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  • Understanding of physiological pH and its effects on amino acid charges
  • Knowledge of acid-base reactions, particularly in organic chemistry
  • Familiarity with ionic interactions in biological systems
  • Basic concepts of molecular biology, including nucleotide triphosphates
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  • Research the role of charged amino acids in protein interactions
  • Explore the mechanisms of ion association with biomolecules like ATP
  • Investigate the impact of ionic strength on cellular processes
  • Learn about the equilibrium dynamics of ions in biological systems
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Biochemists, molecular biologists, and researchers interested in cellular interactions and the behavior of ions in physiological conditions.

vande060
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For example:

amino acids that are floating around, some with charge at physiological pH. My question is what exactly do the charged amino acids form a salt with? other amino acids? sugars? fatty acids? whatever happens to have an opposite charge and is close?

A rephrasing: I am thinking about how how in o chem acid base reactions we added sodium hydroxide to a solution of benzoic acid to create the conjugate base of benzoic acid. In the case the benzoic acid forms a salt with the sodium, so what do the amino acids form salts with in vivo?
 
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Most salts in solution exist as separated ions. If you dissolve table salt in water, you have Na+ ions and Cl- ions in solution, which are not stably associated with each other. In the same way, most of the ions inside the cell are not stably associated with counter ions.

There are, of course, exceptions to this rule. For example, Mg2+ fairly stably associates with nucleotide triphosphates like ATP, and various proteins or other biomolecules often have specific charged sites that will stably bind ions from solution.
 
vande060 said:
For example:

amino acids that are floating around, some with charge at physiological pH. My question is what exactly do the charged amino acids form a salt with?

Do they need to? Equilibrium conditions favour the ionic forms of ions like potassium and the various amino acids in the cytosol.
 

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