What is the Best Spreadsheet Application for Scientists?

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nameman
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what goes in the blank?
 
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What's wrong with Excel? What do you need to do that Excel doesn't do? Using a programming language is probably the best fit.
 
Mostly just wondering what people think completes the analogy.
 
I like Serena said:
"OpenOffice.org Calc", which is Excel in Linux.

I prefer LibreOffice now. They're both cross platform.

For serious number crunching I use Python and MATLAB.
 
Gnumeric is also a good spreadsheet application.