First quantization involves replacing position with an operator while treating time as a parameter, which does not fully accommodate relativity. In contrast, second quantization, or Quantum Field Theory, treats both time and position as parameters, allowing for a unified treatment of particles and fields. This approach respects the principles of relativity and simplifies the handling of identical particles through operator commutation properties. The distinction lies in how wave functions are treated, with second quantization providing a more comprehensive framework. Understanding these concepts is essential for grasping advanced quantum mechanics.