What would be some degradation products of these compounds?

In summary, the compounds discussed in the conversation could potentially degrade into alcohols and undergo hydrolysis and oxidation reactions. The pH could also be affected by atmospheric moisture, making the CN group hydrolyzable. It is suggested to check the literature or conduct experiments to determine the specific types of degradation these drugs may undergo.
  • #1

In terms of drug shelf life, what might those compounds degrade into over time? For compound 1, that the azole rings CH3 group as well as the carbons attached to the sulfur could undergo autooxidation to alcohols. I can also see that atmospheric moisture could lower the pH (due to dissolved CO2) and make the CN group hydrolyzable. For compound 2, I can see some potential for oxidation and hydrolysis too but I can't think of anything other than hydrolysis and oxidation reactions for either of these compounds. What other types of degradation could these drugs undergo?
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  • #2
Have you checked the literature? Using empirical rules to try and predict phenomena is okay; ultimately you need to run experiments (or check to see if someone else has already done the work) to get the answer.

Related to What would be some degradation products of these compounds?

1. What are degradation products?

Degradation products are substances that are formed when a compound breaks down or degrades. This can happen due to various factors such as exposure to light, heat, or chemical reactions.

2. How are degradation products formed?

Degradation products are formed through a process called degradation, which involves the breaking down of a compound into smaller molecules. This can occur through various mechanisms such as hydrolysis, oxidation, or photolysis.

3. What factors can contribute to the formation of degradation products?

The formation of degradation products can be influenced by several factors such as temperature, pH, exposure to light or oxygen, and the presence of catalysts or impurities. These factors can accelerate the degradation process and lead to the formation of different products.

4. Are degradation products harmful?

It depends on the specific compound and its degradation products. Some degradation products may be harmless or even beneficial, while others can be toxic or have undesirable effects. It is important to study and understand the degradation products of a compound to determine their potential risks.

5. How can the formation of degradation products be prevented?

The formation of degradation products can be prevented by storing the compound in appropriate conditions, such as in a cool and dark environment, and avoiding exposure to factors that can accelerate degradation. Additionally, using stabilizers or antioxidants can help to slow down the degradation process.

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