When Fungi Attack!

  • Thread starter Hercuflea
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CDC identifies first US cases of drug-resistant fungal infection
http://www.cnn.com/2016/11/04/health/drug-resistant-c-auris-found-in-us/

I heard on the radio that several of these patients died because the doctors did not recognize the disease and didn't properly diagnose it.

As someone with psoriasis/eczema, I'm susceptible to fungal infections and this does concern me.

What do you think?
 

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  • #2
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http://www.cdc.gov/fungal/diseases/candidiasis/candida-auris.html
"C. auris is difficult to identify with standard laboratory methods and can be misidentified in labs without specific technology. CDC encourages all U.S. laboratory staff who identify C. auris strains to notify their state or local public health authorities and CDC at candidaauris@cdc.gov."

It appears that the CDC has been pushing for stricter standards "In 2013, CDC issued a report describing antibiotic resistance threats in the United States that needed prompt action, including Candida infections." I think it's part of a larger problem involving globalization in general and global environmental change. One of the members of my subgroup in the American Geophysical Union's Global Environmental Focus Group is an epidemiologist and when we meet we plot changes on a huge wall map, sit back with our glasses of wine and say, "Oh, s***." when things seem to be converging. In the cases of diseases, we clearly need to be more vigilant than in the past.
 
  • #3
jim mcnamara
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Superbugs arise from over prescribing/overuse of antibiotics and antibiotic abuse. It is not always the failure of a medical professional to identify or recognize a pathogen, (while dangerous for a given patient), that is the real problem. Some other issues:

1. Iatrogenic infections - On a routine visit, I am exposed to pathogens in a medical facility that have been in and around antibiotics in patients and survived. Maybe bugs are resident in air conditioning ducts, as a simple-minded example. I pick up something from exam equipment that lay in the open for a few minutes. Voila.

2. I take antibiotics, but don't follow directions. A patient compliance failure. Like stopping antibiotics early. I build my very own personal supply of resistant bugs this way. Example: Tuberculosis patient is on drugs with unpleasant side effects for long periods. So, the patient gets p*** off, stops the meds early. Then TB symptoms return. The patient now has to use another possibly more unpleasant drug because the TB bacteria have become resistant to the previous drug. Wash, rinse, repeat - and patient now has is own supply of TB superbugs. Which he can now freely donate to friends and neighbors.

3. Taking antibiotics when there is no good reason to do so. Example: taking antibiotics meant to control bacterial infections for a virus infection. Many third world countries have very powerful antibiotics available from street vendors. Physicians are often few and far between. Example: Every time I get sick with a cold or the flu, I buy Amoxicillin or whatever from a vendor. I am creating the same situation for myself as in #2 above.
 
  • #5
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What about the fact that this is a fungal infection makes the approach of medical professionals different than if it were a drug resistant bacteria or virus?
 
  • #6
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What about the fact that this is a fungal infection makes the approach of medical professionals different than if it were a drug resistant bacteria or virus?

I'm not sure what you're asking. There are antibacterial, anti fungal and anti viral drugs. There are far more choices among antibacterial drugs than among the other two. However drug resistance is a big problem for antibacterial and increasingly for anti fungal drugs. For C auris specifically, it's hard to diagnose. In my previous post, the failure of a standard fungal infection test is described in the link.
 
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  • #7
Astronuc
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It's back! Or it never went away.

Superbug Fungus Candida Auris Explained As CDC Warns of U.S. Cases: 'Global Health Threat'
https://www.msn.com/en-us/health/me...s-of-us-cases-global-health-threat/ar-AAMtpQ4

Researchers have discovered transmission of a type of drug-resistant fungal infection in Dallas, Texas and Washington, D.C. for the first time in the U.S.

The CDC states it is concerned about C. auris because of its drug resistance, plus the fact that it is difficult to identify without specific technology and because it causes outbreaks in healthcare settings.

I read yesterday that the 3 cases are resistant to three standard treatments.

Most C. auris isolates in the U.S.—around 85 percent—are resistant to the class of antifungal drug called azoles. Around 33 percent are resistant to the antifungal drug amphotericin B, and around 1 percent are resistant to echinocandins.

As such, echinocandin resistance in C. auris is concerning, but this is what has occurred in five U.S. cases reported by the Antibiotic Resistance Laboratory Network between January and April 2021. Three of the cases were in D.C., and two in Texas.

The CDC outlined the cases in its Morbidity and Mortality Weekly Report published July 23. The report's authors wrote that the cases "provide the first evidence suggesting that pan- or echinocandin-resistant C. auris strains might have been transmitted in U.S. health care settings."
 
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pinball1970
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  • #9
Astronuc
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That's great. We have had MRSA and C Diff for a while now, just coming out of a virus pandemic (UK that is....give it a week see where we are) however, fungus...
Don't forget meliodosis
https://www.physicsforums.com/threa...-bacterium-burkholderia-pseudomallei.1004729/

C. diff nearly killed my mother some years back. She was initially misdiagnosed, then a doctor who was familiar with C. diff and knew how to treat it took over her case. We waited overnight to see if she would survive, and fortunately, she recovered. If not for that one doctor, my mother would have died.
 
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