Why do certain drugs need to be freebased and form HCL salts?

  • Thread starter Thread starter thunderfvck
  • Start date Start date
  • Tags Tags
    Hcl
Click For Summary
SUMMARY

Certain drugs require freebasing to convert them into their hydrochloride (HCl) salt form, which enhances their stability and usability. Freebasing involves the reaction of a drug's amine group, which acts as a base, with hydrochloric acid to form a solid salt. This process is advantageous as it transforms the drug from a liquid or oily state into a more manageable solid form, improving handling and dosing accuracy. Understanding the chemistry behind freebasing is crucial for those involved in pharmaceutical formulations.

PREREQUISITES
  • Basic understanding of organic chemistry, specifically amine groups and acid-base reactions.
  • Familiarity with drug formulation processes and the significance of drug solubility.
  • Knowledge of hydrochloric acid (HCl) and its role in forming salts.
  • Awareness of the physical properties of drug compounds in different states (solid vs. liquid).
NEXT STEPS
  • Research the process of freebasing and its implications in drug formulation.
  • Study the chemical properties of hydrochloride salts and their advantages in pharmaceuticals.
  • Explore the differences between freebase and salt forms of various drugs.
  • Learn about the stability and solubility of drugs in different chemical states.
USEFUL FOR

Pharmaceutical chemists, drug formulators, and anyone interested in the chemical processes involved in drug preparation and stability.

thunderfvck
Messages
206
Reaction score
0
Hi.

Certain drugs need to be freebased, can someone explain this (the meaning of freebaing)? Why would you want to freebase?
I believe that when they are freebased they form a salt of HCL or something, what's with that? Is it analogous to hydrated salt, where a compound can hold like 2 moles of water within its structure? Why HCl?
 
Chemistry news on Phys.org
A lot of drugs have an amine group that acts like a base. The base reacts with an acid (HCl) to form a salt, the salt is the freebase. THis is advantageous because then you'll have a solid chemical as opposed to the oilly garbage that is the base form.
 

Similar threads

Chemical water treatment: Acid base reaction
  • · Replies 2 ·
Replies
2
Views
3K
Bridging the gap between waters selfionizatio and Le Chatelier
  • · Replies 2 ·
Replies
2
Views
2K
What Do Flame Tests Reveal About Sodium and Chloride?
  • · Replies 6 ·
Replies
6
Views
3K
Figuring Out How Much HCl for Ba(OH)2 Reaction
  • · Replies 4 ·
Replies
4
Views
17K
Is litmus test a reliable criterion for classifying compounds as acids or bases?
  • · Replies 11 ·
Replies
11
Views
5K
Water molecules effect on Hydrogen bonds in precipitation
  • · Replies 2 ·
Replies
2
Views
3K
Temperature Required to Dehydrate a Hydrated Compound
  • · Replies 5 ·
Replies
5
Views
3K
How do voltaic cells generate ions without a salt bridge?
  • · Replies 1 ·
Replies
1
Views
4K
Why Does Copper Change Color During Electrolysis with Kids?
  • · Replies 1 ·
Replies
1
Views
4K
Physics of Water in the Closed System of the Great Pyramid
  • · Replies 15 ·
Replies
15
Views
4K