Why does a Phospholipid have an unsaturated fatty acid tail?

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Discussion Overview

The discussion centers on the structural characteristics of phospholipids, specifically the presence of an unsaturated fatty acid tail alongside a saturated one. Participants explore the implications of this structural variation on the properties and behavior of phospholipid membranes.

Discussion Character

  • Homework-related, Conceptual clarification, Technical explanation

Main Points Raised

  • One participant questions the rationale behind the presence of an unsaturated fatty acid in phospholipids, noting that the textbook does not provide an explanation.
  • Another participant suggests that the inclusion of an unsaturated fatty acid may simply serve as an example to illustrate various properties of phospholipids.
  • A follow-up question is raised regarding the variation in fatty acid chains and whether this affects the phospholipid's properties, particularly in terms of linearity.
  • One participant responds that cis-unsaturated fatty acids pack less efficiently than saturated or trans-unsaturated fatty acids, affecting the fluidity of the phospholipid membrane. They note that a higher proportion of cis-acids contributes to a more fluid membrane, while saturated or trans-unsaturated acids tend to stiffen it.
  • The impact of these variations on the mechanical properties of the membrane and the transport of substances across it is also mentioned.
  • A relevant external resource is provided for further reading on lipid bilayer phase behavior.

Areas of Agreement / Disagreement

Participants express differing views on whether there is a specific reason for the structural variation in fatty acid chains. While some suggest it may be illustrative, others provide insights into the functional implications of these variations, indicating that the discussion remains unresolved.

Contextual Notes

There are limitations in the discussion regarding the assumptions made about the properties of unsaturated versus saturated fatty acids and their specific effects on membrane behavior, which are not fully explored.

Hammad Shahid
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Homework Statement


Hi guys. In the biochemistry chapter, the book shows the structure of a phospholipid (picture attached) with a PO4 3- group and 2 fatty acid chains attached to a glycerol molecule. However, one of the fatty acid chains has a C=C bond while the other is fully saturated. I’m wondering what’s the reason for this.

Homework Equations

The Attempt at a Solution


I looked through the section and it doesn’t give an explanation for it. I also searched it up but I couldn’t find what I was looking for, and the images online had similar structures as well.
Thanks for help.
 

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I doubt there is a "reason", looks like just an example made to show several important properties of such molecules.
 
Borek said:
I doubt there is a "reason", looks like just an example made to show several important properties of such molecules.
Okay thank you. That is what I thought.
So that means there’s variation in the fatty acid chains? And does that affect the phospholipid in any way (if the chains are linear or not)?
 
Yes and yes. cis-unsaturated fatty acids pack less efficiently than trans-unsaturated and saturated fatty acids. A higher proportion of cis-acids causes the phospholipid membrane to behave more as a fluid, whereas a higher proportion of saturated/trans-unsaturated acids acts to stiffen the phospholipid membrane. The balance of these affects the membrane's mechanical properties as well as the transport of various species across the membrane. Here's a relevant wiki page:
https://en.wikipedia.org/wiki/Lipid_bilayer_phase_behavior
 
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