Why mother's DNA and not mitochondria transplanted into egg?

In summary, the conversation discusses the concept of "3 parents baby" and how it involves taking the egg of a mitochondria donor, removing its nucleus and transplanting the mother's DNA to create an egg with healthy mitochondria and DNA. The question is posed as to why they don't simply remove the mitochondria and transplant new ones into the mother's egg to avoid altering the DNA. The reason for this is that each cell requires a large number of mitochondria, making it difficult to swap them between cells.
  • #1
cave_cat
41
0
I am referring to "3 parents baby" discussed e.g. here http://www.economist.com/news/leade...s/when-did-mitochondria-evolve/"]mitochondrial-diseases-should-be-permitted-law-powering[/url] . AFAIU they take the egg of mitochondria donor, remove its nucleus / DNA and transplant into it the mother's DNA, thus creating an egg with good mitochondria and, allegedly, correct / undamaged DNA.

So I am wondering, why don't they remove (destroy?) mitochondria and transplant new ones into mother's egg instead, not touching the DNA at all? Are there too many mitochondria in the egg to easily achieve that? Or what is the underlying rationale?
 
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  • #2
cave_cat said:
Are there too many mitochondria in the egg to easily achieve that?

Yes, each cell requires very many mitochondria, so it would be nearly impossible to swap mitochondria between cells.
 

1. Why is the mother's DNA transplanted into the egg instead of the mitochondria?

The mother's DNA contains the majority of the genetic information that determines the characteristics and traits of an individual. Mitochondria, on the other hand, play a specific role in energy production and do not contribute to an individual's physical characteristics. Therefore, it is necessary to transplant the mother's DNA into the egg to ensure that the resulting individual inherits their mother's genetic traits.

2. Can't the mitochondria be transplanted instead of the mother's DNA?

Technically, it is possible to transplant mitochondria from one individual into another egg cell. However, this would result in the resulting individual having DNA from two different individuals, which can lead to complications and potential health risks. Therefore, it is safer and more ethical to transplant the mother's DNA into the egg.

3. What is the role of mitochondria in the egg?

Mitochondria are responsible for producing the energy needed for the cell's functions. In the case of egg cells, they are crucial for providing the energy required for fertilization and the development of the embryo after fertilization. Therefore, they play an essential role in the reproductive process.

4. Are there any potential risks associated with mitochondrial transplant into the egg?

While mitochondrial transplant is a relatively new technique, studies have shown that the procedure is generally safe. However, as with any medical procedure, there may be potential risks, such as genetic abnormalities or complications during the transplant process. It is essential to continue research and closely monitor the safety and efficacy of this technique.

5. Can mitochondrial transplantation into the egg result in genetic modification?

No, mitochondrial transplant does not involve altering the genetic information within the DNA. It only involves transferring the DNA from the mother's egg into the donor egg, which does not result in genetic modification. Therefore, the resulting individual would still have the same genetic traits and characteristics inherited from their biological mother.

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