If the problem of retroviral infection is, like for example HIV, viral DNA segment integration in human DNA of immune system cells, why cannot be the same or similar method as used in treatment of patients with leukemia or blood cancers be applied here? What is preventing this? Couldn't infected immune system cells be destroyed with radiation and a new transfusion of blood and bone marrow transplant from donor? Couldn't be remaining viruses and infected immune system cells in blood be externally separated (filtered/collected - something like in kidney failure paitents)? Wouldn't such procedures eradicate the virus and remove infected immune system cells? The new healthy ones from donor would then in absence of viruses repopulate the patient. It would be risky, given the low immunity of such patient, but if blood cancer patients can survive such procedures, why couldn't this be helpful for aids patients? Wouldn't surgical removal of lymph nodes and spleen, combined with radiation, blood transfusion and bone marrow transplant eradicate hiv and cure aids? ..so, why is such procedure not working here (the analogy with blood cancer treatment)? Is it because infected immune system cells are not limited only to blood and are present in hard tissues too? Even if viruses could not be separated from blood but only infected immune system cells could, wouldn't new integrase inhibition drugs prevent integration of new retroviral DNA segments in newly recieved healthy immune system cells from donor? ..thanks to anyone for clarification of this topic.