Adjusting Parameters for Identifying Features of an Action Potential

In summary, the conversation involves finding a formula for an action potential, using it to graph in the Desmos graphics calculator, and exploring different approximations. Various functions are suggested, including a difference of two exponentials, a Crystal Ball function, and a piecewise continuous function. The conversation then shifts to finding a more precise solution, with a formula of 6*exp(-x^2*36)-exp(-(x-0.4)^2) being chosen and modified to fit the desired shape and values. The process involves adjusting parameters and subtracting 70 to get the baseline and peak heights right.
  • #36
TULC said:
You suggested a couple of things in a previous post including (1) enabling users to enter arbitrary equations similar to Desmos
Yes, this could be implemented using the excellent expression parser in math.js.

TULC said:
(2) changing audio parameters...Both of these suggestions are great, though I would like to learn more. Which audio parameters could we actually adjust in this application?
Well the code has these default settings (see https://github.com/avplot/avplot.gi...0bed551481c708dcb9e10/src/avplot/avplot.js#L9)
JavaScript: 
const defaults = {
  animationDuration: 5000,
  highlightPointRadius: 6,

  maxGain: 0.25,
  valueScale: 1,
  valueOffset: 0,
  // const baseFreq = 440; // A5.
  // const baseFreq = 523.23; // C5.
  baseFrequency: 880, // A6.
  octaveScale: 2,
  octaveOffset: 0,
};
, you can see where I have experimented with different base frequencies for instance. All it needs is a user interface to adjust these (and it would be even easier to build these into a URL e.g. https://avplot.com/#/hodgkin-huxley/settings=baseFreq:440,octaveScale:2 (note this is not implemented and shows a blank screen at the moment).

TULC said:
Regarding this particular sonification: It could be useful to adjust the function such that the users can more easily identify specific features of an action potential. Specifically, it would be helpful to make the undershoot following the fall of the curve a bit more pronounced, e.g., by increasing its amplitude. It would be good to experiment with that particular feature of the curve. Currently, without any visual input, I would not be able to identify that there is an undershoot following the fall of the curve.
Parameters could be introduced to expand the freqency range for e.g. the lower part of the curve which would highlight the detail in this case.
 
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<h2>1. What is an action potential?</h2><p>An action potential is a rapid change in the electrical potential of a cell, particularly in neurons or muscle cells. It is the basis for nerve impulse transmission and muscle contraction.</p><h2>2. Why is it important to adjust parameters for identifying features of an action potential?</h2><p>Adjusting parameters allows for a more accurate and precise identification of the various characteristics of an action potential, such as the threshold, amplitude, and duration. This can help in understanding the underlying mechanisms of nerve and muscle function.</p><h2>3. What are some common parameters that are adjusted for identifying features of an action potential?</h2><p>Some common parameters include the stimulus intensity, duration, and frequency, as well as the recording electrode placement and filtering settings.</p><h2>4. How do scientists determine the optimal parameters for identifying features of an action potential?</h2><p>Scientists often use a trial and error approach, systematically adjusting parameters until they obtain a clear and consistent action potential waveform. They may also refer to established protocols or consult with other researchers in the field.</p><h2>5. Can adjusting parameters affect the results of an experiment on action potentials?</h2><p>Yes, adjusting parameters can significantly impact the results of an experiment. It is important to carefully select and document the parameters used to ensure the validity and reproducibility of the findings.</p>

1. What is an action potential?

An action potential is a rapid change in the electrical potential of a cell, particularly in neurons or muscle cells. It is the basis for nerve impulse transmission and muscle contraction.

2. Why is it important to adjust parameters for identifying features of an action potential?

Adjusting parameters allows for a more accurate and precise identification of the various characteristics of an action potential, such as the threshold, amplitude, and duration. This can help in understanding the underlying mechanisms of nerve and muscle function.

3. What are some common parameters that are adjusted for identifying features of an action potential?

Some common parameters include the stimulus intensity, duration, and frequency, as well as the recording electrode placement and filtering settings.

4. How do scientists determine the optimal parameters for identifying features of an action potential?

Scientists often use a trial and error approach, systematically adjusting parameters until they obtain a clear and consistent action potential waveform. They may also refer to established protocols or consult with other researchers in the field.

5. Can adjusting parameters affect the results of an experiment on action potentials?

Yes, adjusting parameters can significantly impact the results of an experiment. It is important to carefully select and document the parameters used to ensure the validity and reproducibility of the findings.

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