Bob S is spot on..plus the V12 fires every 30 degrees of crankshaft rotation vs. firing every 45 degrees in the V8..so the V12 is SMOOOOOOTH..but consider
V12 is heavy, compared to the V8 block, you have more parasitic drag of additional 4 pistons, rings, 4 more rod bearings, probably two more main bearings, heavier intake manifold with more intake runners, heavy longer crankshaft, cam shaft, a lot more drag to open 8 to 16 more valves.
it mat be worth it if you can up the cubic inch displacement but consider the size of the block...it really takes up a big footprint in the engine room so you got one long hood...also the damn thing will be nose heavy and hooking up the rear drive tires will be tuff..
consider a V8 with aluminum cylinder heads can put out 650 horsepower and weighs just over 300 pounds...and iaa very compact package...