Antiparticles are real particles with positive energy, capable of existing in the vacuum of space, while virtual particles are temporary fluctuations that do not exist at the end of a process and can transport negative energy. Antiparticles can be created and studied in laboratories, as seen in applications like PET scanners. In contrast, virtual particles are often discussed in the context of quantum mechanics and phenomena like Hawking radiation, where they appear in pairs and do not violate conservation laws. The interaction between these particles can lead to energy exchanges, with one virtual particle potentially becoming a real particle while the other vanishes. Understanding the distinction between these two types of particles is crucial for grasping concepts in quantum physics and black hole mechanics.