Negri bodies are indeed present in humans who have died from rabies, serving as post-mortem diagnostic indicators of the disease. These bodies are viral particle inclusions, specifically ribonuclear proteins, resulting from the high viral load in certain neuron types, particularly in the hippocampus. While they confirm rabies infection post-mortem, their utility in living patients is limited. For early detection, an ELISA test is recommended, although it remains uncertain in effectiveness, and rabies prophylaxis is advised for those at high risk.
PREREQUISITESThis discussion is beneficial for medical professionals, virologists, and public health officials involved in infectious disease management, particularly those focusing on rabies and its diagnostic challenges.
