Are There Any Clinical Studies on the Effects of Marijuana?

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Discussion Overview

The discussion centers around the availability of clinical studies on the effects of marijuana, particularly in relation to its impact on the human body. Participants are seeking specific studies, sources, and information regarding the endocannabinoid system and its implications in various health contexts such as pain, memory, neurodegeneration, and inflammation.

Discussion Character

  • Exploratory
  • Technical explanation
  • Debate/contested

Main Points Raised

  • Some participants express surprise at the perceived lack of studies on marijuana and its effects, citing a specific quote from a 2003 article in Nature Medicine regarding the endocannabinoid system.
  • One participant notes that there are 1183 hits on PubMed for marijuana and clinical trials, suggesting a wealth of research available.
  • Another participant mentions the difficulty in accessing specific studies without financial commitment, highlighting the challenge of finding free resources.
  • A participant shares a link to a study indicating that THC affects memory through astrocytes rather than neurons, suggesting a specific mechanism of action.
  • Several participants discuss the need for citations and direct links to studies, with some expressing frustration over the lack of accessible information.
  • Granny Storm Crow's List is mentioned as a comprehensive resource for articles on the medical use of cannabis, which may aid in research efforts.
  • Links to Wikipedia articles on medical cannabis and related health issues are shared, although their reliability and depth are not universally accepted among participants.

Areas of Agreement / Disagreement

Participants do not reach a consensus on the availability of studies or the accessibility of information, with some expressing frustration over the lack of direct citations and others pointing to resources that may be helpful.

Contextual Notes

Participants note limitations in accessing certain studies due to paywalls and the need for specific search terms to find relevant research on PubMed.

Alfi
http://www.scientificamerican.com/article.cfm?id=marijuana-research

After reading this article, I tried to find any studies.

I am stunned if there really are not any studies on this substance and it's affects to the human body.

Please post any links you may know of.

I see this quoted often, but I cannot find a direct link.
As the journal Nature Medicine put it in 2003, "the endocannabinoid system has an important role in nearly every paradigm of pain, in memory, in neurodegeneration and in inflammation."
Thank you for any help in tracking down a link to the source of this quote.

or examples like this.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358713/?tool=pubmed
 
Last edited by a moderator:
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There are 1183 hits on Pubmed for marijuana and clinical trials.
 
Monique said:
There are 1183 hits on Pubmed for marijuana and clinical trials.

Thank you.
 
double post . sorry.

what was the source to the quote again? sorry I missed it.
 
It's a news article, but it doesn't cite the exact studies:
http://www.nature.com/nm/journal/v9/n10/full/nm1003-1227.html

You can find studies by searching PubMed for the keywords pain, memory, neurodegeneration, or inflammation and marijuana. You can use the tag [tiab] to only search the title+abstract for the keywords (thus getting more relevant results).
 
Last edited by a moderator:
It's a news article, but it doesn't cite the exact studies:

ah ... you see my problem.

What does cite the exact studies? without a $$$ commitment?
To read this story in full you will need to login or make a payment
As the journal Nature Medicine put it in 2003, "the endocannabinoid system has an important role in nearly every paradigm of pain, in memory, in neurodegeneration and in inflammation."Thank you for any help in tracking down a link to the source of this quote.
 
When I was studying astrocytes, I cam across this:

http://www.ncbi.nlm.nih.gov/pubmed/22385967

Which indicates that astrocytes have a lot to do with working memory, but also that THC actually acts on CB1 receptors in astrocytes to have memory impairment effects, NOT neurons!
 
thank you also. but still no link to the quote.
 
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  • #10
Thank you.

I found that one. I was hoping to get around the $ This is very good information to help me in my investigations.
Thank you all. :)
 
  • #11
Alfi said:
Thank you.

I found that one. I was hoping to get around the $


This is very good information to help me in my investigations.
Thank you all. :)
ooops, I missed that. Sorry.
 
  • #12
As I mentioned, the news report is not informative as it doesn't list the citations. On PubMed there are freely accessible papers available, you can tick a box to only reveal those in your search.
 
  • #13
Alfi said:
I see this quoted often, but I cannot find a direct link.

As the journal Nature Medicine put it in 2003, "the endocannabinoid system has an important role in nearly every paradigm of pain, in memory, in neurodegeneration and in inflammation."


Thank you for any help in tracking down a link to the source of this quote.


The quote you are asking about is a quote relating to the endocannabinoid system. Your research should begin with the search term, "endocannabinoid system" rather than "marijuana pain neurodegeneration inflammation".


See this, for example.
 
  • #14
Granny Storm Crow's List is a fairly complete compilation of articles written about the medical use of cannabis. The January 2012 list is available at this link:

www.letfreedomgrow.com/cmu/GrannysListJan2012.pdf

Articles are grouped alphabetically by topic. It is an indispensable resource for anyone beginning research on medical marijuana.
 

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