Calculating the expression log_2(log_3(65)) + 3*log_5(log_5(9) is challenging without a calculator, as it involves complex logarithmic functions. Despite attempts to simplify using the change of base formula, users found it complicated and unable to yield the expected answer of 3. The discussion highlights that calculators are essential for evaluating such logarithmic expressions accurately. Some users noted discrepancies in answers, with one mentioning a calculator result of 2.506, likely due to rounding. Ultimately, the consensus is that for complicated logarithmic calculations, using a calculator is advisable.